Principles of satiation
GLP1 decreases food intake in several species 51 , 52 , including humans There are two types of peripheral signals: Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans. Hormone levels also change when we lose weight. Leptin is the chemical that tells the brain that the body is satiated.
This could theoretically lead to reduced appetite and cravings (2). There are actually a whole bunch of studies in rats showing that Garcinia Cambogia consistently leads to significant weight loss (3, 4, 5, 6).
However, what works in rats doesnt always work in humans. Bottom Line: Studies in rats show that the active ingredient in Garcinia Cambogia can inhibit a fat producing enzyme called Citrate Lyase and increase serotonin levels, leading to significant weight loss.