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Only one of 10 mice treated with anti-CD47 had a lymph node with signs of cancer. Those responsible for the huge world crisis of the present time insist on continuing down the path that led to this disaster. With properly prepared soybean material and sufficient extraction time, it is often possible to achieve about 0. This carbohydrate is absolutely required in the extrusion process; dry pet foods are essentially breakfast cereal for pets with a little added meat meal for palatability. Diagram of countercurrent flow. To illustrate this problem, let's go back in recent history. Yeast extract is also used in so-called "natural" veggie burger products sold in grocery stores and health food stores.

In This Issue

Hemp Oil: Benefits, Nutrition, Side Effects and Facts

Prospective, Observational Study Evaluating the Treatment in Cancer Patients on Supportive or Palliative Care The potential relevance of the endocannabinoid, 2- arachidonoylglycerol, in diffuse large B-cell lymphoma The role of cannabinoids in prostate cancer: Cannabidivarin CBDV suppresses pentylenetetrazole PTZ -induced increases in epilepsy-related gene expression Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.

Allosteric Modulation of the Cannabinoid CB1 Receptor Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L. CB2 cannabinoid receptors as an emerging target for demyelinating diseases: A Promising Impact for Traumatic Brain Injury Endocannabinoids and traumatic brain injury Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors Mechanisms of cannabidiol neuroprotection in hyopoxic-ischemic newborn pigs: Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis Keep off the grass Cannabis?

Can You Pass the Acid Test? Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation Regulation of nausea and vomiting by cannabinoids The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes.

Site and Mechanism of Action Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors Cannabinoid pharmacology: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol Endocannabinoid Signaling Regulates Sleep Stability Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol Enhanced discriminative stimulus effects of 9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: Importance for development and in pediatric disease The Endocannabinoid System as an Emerging Target of Pharmacotherapy The Endocannabinoid System, Cannabinoids, and Pain The endocannabinoid system in normal and pathological brain ageing The endogenous cannabinoid system and its role in nociceptive behavior The orphan receptor GPR55 is a novel cannabinoid receptor.

An Acute Slice Electrophysiological Study Presence of functional cannabinoid receptors in human endocrine pancreas The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat.

Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine Cannabidivarin CBDV suppresses pentylenetetrazole PTZ -induced increases in epilepsy-related gene expression Cannabidivarin is anticonvulsant in mouse and rat Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism Cannabinoids for pediatric epilepsy?

Up in smoke or real science? A Scientific Review CBD-enriched medical cannabis for intractable pediatric epilepsy; The current Israeli experience Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients On the application of cannabis in paediatrics and epileptology Parent use of cannabis for intractable pediatric epilepsy: Everyday empiricism and the boundaries of scientific medicine Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy The case for assessing cannabidiol in epilepsy The case for medical marijuana in epilepsy The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy Understanding Cannabinoids and Epilepsy.

Delta-9 tetrahydrocannabinol THC inhibits lytic replication of gamma oncogenic herpesviruses in vitro. Cannabinoids and Cystic Fibrosis: A Novel Approach to Etiology and Therapy. Clearing Away the Smoke Pharmacological actions and therapeutic uses of cannabis and cannabinoids Phytocannabinoids beyond the Cannabis plant — do they exist? Delta-9 tetrahydrocannabinol THC inhibits lytic replication of gamma oncogenic herpesviruses in vitro The effect of deltatetrahydrocannabinol on herpes simplex virus replication Cannabinoids as pharmacotherapies for neuropathic pain: Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

Short-term efficacy of CBD-enriched hemp oil in girls with dysautonomic syndrome after human papillomavirus vaccination. Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties Cannabinoids and the immune system CB2 cannabinoid receptors as an emerging target for demyelinating diseases: Endocannabinoids, feeding and suckling — from our perspective Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease.

Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol — studies in BV-2 microglia and encephalitogenic T cells Anti-Inflammatory Role of Cannabidiol and O in Cerulein-Induced Acute Pancreatitis in Mice Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: Clinical endocannabinoid deficiency CECD revisited: Cannabinoids inhibit neurodegeneration in models of multiple sclerosis CB2 cannabinoid receptors as an emerging target for demyelinating diseases: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice Endocannabinoids in Liver Disease Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains.

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: Evidence from Cannabidiol Treatment The cannabinoid receptor agonist WIN facilitates the extinction of contextual fear memory and spatial memory in rats Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons.

Implications for Neuropsychiatric Disorders Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances Cannabidiol as a potential treatment for psychosis Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia Cannabidiol, neuroprotection and neuropsychiatric disorders Cannabidiol reverses MKinduced disruption of prepulse inhibition in mice Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence Cannabinoids in bipolar affective disorder: Activation of CB2 receptors as a potential therapeutic target for migraine: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: Implications in Migraine The endocannabinoid system and migraine.

Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors Cannabinoid Modulation of Neuroinflammatory Disorders Cannabinoids and multiple sclerosis Cannabinoids control spasticity and tremor in a multiple sclerosis model Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis CAMS study: Role of the Corticospinal Modulation Smoked cannabis for spasticity in multiple sclerosis: Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection The effect of cannabis on tremor in patients with multiple sclerosis The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation Cannabinoid Regulation of Acute and Anticipatory Nausea Interaction between non-psychotropic cannabinoids in marihuana: Cannabinoid—Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations "The Therapeutic Potential of Cannabinoids for Movement Disorders Nervous System".

As this damage accumulates, it adversely affects the gastrointestinal, immune, and other systems of humans and other animal species. Second, they exist in a symbiotic relationship with Rhizobium bacteria. By fixing atmospheric nitrogen in the roots of the soybean plant, the lectin-bacteria team supports the miracle bean's traditional, historical use as a fertilizer and crop rotator.

Usually, soy lectins are digested and inactivated by traditional fermentation or by heat in soy processing. However, it has been found that "soybean meals can, on occasion, retain functional lectins at levels that may be detrimental to the animal's health and productivity. Then, "lectins are more than capable of perturbing digestive, absorptive, protective, and secretory functions throughout the gastrointestinal tract. Unlike ordinary food proteins, lectins strongly resist breakdown by enzymes in the gut.

However, if they eat the soy protein regularly, as a principal source of protein, they are asking for problems from lectins and the many other anti-nutrients in soy. Saponins are another anti-nutrient, along with protease inhibitors, phytates, and lectins, which all seem "to have evolved to help plants defend themselves against microbes, insects, and animal predators. In the case of the drug, "side effects include pronounced damage to the patient's own cell membranes, with users complaining of gas, diarrhea, nausea, and stomach pain.

Cooking and boiling does not remove saponins. When soy protein is removed from the oil, saponins stick with the protein. A bacterial enzyme, used in the fermentation that produces miso and tempeh, metabolizes and breaks down soy saponins. Saponins do lower cholesterol and may by themselves become a drug. Soy is not the only goitrogenic food. Broccoli, cabbage, Brussels sprouts, cassava, rapeseed, turnips, mustard, radish, peanuts, and millet also contain goitrogens.

However, few adults-and even fewer children-eat these foods to excess. Furthermore, the goitrogens in most of these foods are easily neutralized by cooking or fermentation. Soy foods are different. The principal goitrogens in soybeans are the estrogenic plant hormones known as isoflavones. The antinutrients known as saponins in soy may also be goitrogens. Cooking and processing methods, using heat, pressure, and alkaline solutions, will neither deactivate nor remove isoflavones or saponins.

Only solvent extraction can do that. America is plagued by an epidemic of thyroid problems. Cancer can be promoted by hormone mimickers, like the plant estrogens in soy. These so-called phytoestrogens are also suggested for "natural hormone replacement therapy" and as possible new cancer drugs.

Daniel describes other major problems from consumption in large amounts of the recently developed soy foods, including soy allergies. Oil is extracted from soy that is usually pesticided and often genetically engineered.

Fat-loving pesticides concentrate in fats and oils For convenience the soy oil is hydrogenated, producing "trans fats" with their deleterious health effects on all our cell membranes and their great convenience in processed food production. By the s, vegetarians, hippies, environmentalists, and other idealists joined the cry, recommending soy foods as the solution to world hunger, the path to good health, the key to healthy aging, and the way to preserve our environment.

Old-fashioned whole soy foods that contribute to health if eaten in moderation have given way to ersatz products that lead inevitably to malnutrition and disease. Use permitted for non-profit and non-commercial uses or by healthcare professionals in their practice, with attribution to www.

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